Protection against herpes simplex virus infection in mice by Corynebacterium parvum.
نویسندگان
چکیده
Corynebacterium parvum administered in mice prior to herpes simplex virus (HSV) infection significantly protected them against lethal encephalitis. This was seen both with a mouse strain highly susceptible to HSV and with one relatively resistant to HSV. Mice immunosuppressed by cyclophosphamide and showing an increased mortality after HSV infection were also protected by C. parvum pretreatment. However, C. parvum given simultaneously with or after HSV infection did not exert a therapeutic effect.
منابع مشابه
Protection of mice against viral infection by Corynebacterium parvum and Bordetella pertussis.
Mice could be significantly protected against infection with herpes simplex virus (HSV) by i.p. or i.v. injection of killed Corynebacterium parvum 7 days before infection. This protection was seen in inbred strains of mice with a different degree of sensitivity to HSV and after both i.p. and i.v. infection. Resistant mice immunosuppressed by X-irradiation and showing an increased susceptibility...
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عنوان ژورنال:
- Infection and immunity
دوره 16 1 شماره
صفحات -
تاریخ انتشار 1977